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Fucosyltransferases Regulated by Fusobacterium Nucleatum and Act as Novel Biomarkers in Colon Adenocarcinoma.
Wang P, Liu X, Yu J, Meng Z, Lv Z, Shang C, Geng Q, Wang D, Xue D, Li L. Wang P, et al. J Inflamm Res. 2023 Feb 21;16:747-768. doi: 10.2147/JIR.S396484. eCollection 2023. J Inflamm Res. 2023. PMID: 36852302 Free PMC article.
COAD patients with a high expression of FUT1, FUT11, FUT13 (POFUT2) had a worse prognosis, while patients with a high expression of FUT2, FUT3, FUT6 had a better prognosis. FUT1 and POFUT2 could independently predict the prognosis of COAD patients. Functional analysis by C …
COAD patients with a high expression of FUT1, FUT11, FUT13 (POFUT2) had a worse prognosis, while patients with a high expression of FUT2, FU …
Molecular cloning and expression of a bovine alpha(1,3)-fucosyltransferase gene homologous to a putative ancestor gene of the human FUT3-FUT5-FUT6 cluster.
Oulmouden A, Wierinckx A, Petit JM, Costache M, Palcic MM, Mollicone R, Oriol R, Julien R. Oulmouden A, et al. J Biol Chem. 1997 Mar 28;272(13):8764-73. doi: 10.1074/jbc.272.13.8764. J Biol Chem. 1997. PMID: 9079712 Free article.
Only one bovine gene, corresponding to the human cluster of genes FUT3-FUT5-FUT6, was found by Southern blot analysis. The cognate bovine alpha(1,3)-fucosyltransferase shares 67.3, 69.0, and 69.3% amino acid sequence identities with human FUC-T3, FUC-T5, and FUC-T6 enzymes …
Only one bovine gene, corresponding to the human cluster of genes FUT3-FUT5-FUT6, was found by Southern blot analysis. The cognate bo …
Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population.
Duell EJ, Bonet C, Muñoz X, Lujan-Barroso L, Weiderpass E, Boutron-Ruault MC, Racine A, Severi G, Canzian F, Rizzato C, Boeing H, Overvad K, Tjønneland A, Argüelles M, Sánchez-Cantalejo E, Chamosa S, Huerta JM, Barricarte A, Khaw KT, Wareham N, Travis RC, Trichopoulou A, Trichopoulos D, Yiannakouris N, Palli D, Agnoli C, Tumino R, Naccarati A, Panico S, Bueno-de-Mesquita HB, Siersema PD, Peeters PH, Ohlsson B, Lindkvist B, Johansson I, Ye W, Johansson M, Fenger C, Riboli E, Sala N, González CA. Duell EJ, et al. Int J Cancer. 2015 Feb 15;136(4):880-93. doi: 10.1002/ijc.29034. Epub 2014 Jul 1. Int J Cancer. 2015. PMID: 24947433 Free article.
One variant in FUT5 was also associated with diffuse-type GC, and four variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 with intestinal-type GC. Further, one variant in ABO, two in FUT3 and two in FUT6 were associated with H. pylori infection status …
One variant in FUT5 was also associated with diffuse-type GC, and four variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 wit …
GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians.
Nongmaithem SS, Joglekar CV, Krishnaveni GV, Sahariah SA, Ahmad M, Ramachandran S, Gandhi M, Chopra H, Pandit A, Potdar RD, H D Fall C, Yajnik CS, Chandak GR. Nongmaithem SS, et al. Hum Mol Genet. 2017 Jul 1;26(13):2551-2564. doi: 10.1093/hmg/ddx071. Hum Mol Genet. 2017. PMID: 28334792 Free PMC article.

We replicated previously reported variants rs602662, rs601338 in FUT2, rs3760776, rs708686 in FUT6, rs34324219 in TCN1 (all P < 5 10-8), rs1131603 in TCN2 (P = 3.4 10-5), rs12780845 in CUBN (P = 3.0 10-3) and rs2270655 in MMAA (P = 2.0 10-3). ...Hence, the rs78060698 va

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We replicated previously reported variants rs602662, rs601338 in FUT2, rs3760776, rs708686 in FUT6, rs34324219 in TCN1 (all P < 5

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Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.
Cameron HS, Szczepaniak D, Weston BW. Cameron HS, et al. J Biol Chem. 1995 Aug 25;270(34):20112-22. doi: 10.1074/jbc.270.34.20112. J Biol Chem. 1995. PMID: 7650030 Free article.
FUT3 and FUT6 were expressed at high levels, while FUT5 expression was lower and restricted to fewer cell types. ...No detectable alpha(1,3)- or alpha(1,4)-fucosyltransferase activity was found in assays of cells transfected with FUT6 isoform cDNAs. Thus, tissue-spe …
FUT3 and FUT6 were expressed at high levels, while FUT5 expression was lower and restricted to fewer cell types. ...No detectable alp …